<section style="color: #3e3e3e;"> <section> <p><span style="color: #000000;">细胞器标志物抗体是细胞生物学中常用的研究工具。靶向特定的抗体有助于了解蛋白的亚细胞定位以及探究其生物功能，也可以在细胞器分离提取物的蛋白质印迹分析中用作阳性对照。</span></p> </section> </section> <section style="color: #3e3e3e;"> <section> <p><span style="color: #000000;">核仁（nucleolus）是真核细胞间期核中的结构，通常表现为单一或多个匀质的球形小体。它位于细胞核内，主要由蛋白质、DNA和RNA组成，可分为<span class="wx_search_keyword_wrap">纤维中心</span>（Fibrous Center, FC），致密纤维组分（Dense Fiber Component, DFC），颗粒组分（Granular Component, GC）以及致密纤维组分外围（Periphery of Dense Fiber Component, PDFC）四部分。核仁主要负责rRNA的合成、加工以及<span class="wx_search_keyword_wrap">核糖体亚单位</span>的组装，可参与调节基因表达，与细胞周期的进程密切相关，对染色体的结构和功能有重要影响。</span></p> </section> </section> <section style="color: #3e3e3e;"> <section></section> </section> <section style="color: #3e3e3e;"> <section></section> </section> <section style="color: #3e3e3e;"> <section> <p><span style="color: #000000;"><strong>核仁素</strong>（Nucleolin，简称NCL或C23）是一种在真核生物核仁中高度表达的蛋白质，常用作核仁的标志物。它主要位于核仁的致密纤维状区域，在细胞核、细胞质和细胞膜中也有分布。NCL具有多种生物学功能，包括调控核糖体的生物合成与成熟、参与细胞增殖、生长、胚胎发生、胞质分裂、染色质复制以及抗细胞凋亡等作用。</span></p> </section> </section> <section style="color: #3e3e3e;"> <section><span style="color: #000000;"><img class="rich_pages wxw-img" src="https://img45.chem17.com/9/20240628/638551680824382644376.png" alt="图片" crossorigin="anonymous" data-imgfileid="502583117" data-ratio="0.8696581196581197" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/doiafjfLyzUISu4J0w7b2kwM886QRHvh6yaQ1I8JzuA7navh5eibUA7ebSSqPlbwcGPPVQxD3rH5OClSOOa55nLQ/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="468" data-original-style="vertical-align: middle;width: 100%;" data-index="4" data-sec-load-status="2" /></span></section> </section> <section style="color: #a0a0a0;"> <p><span style="color: #000000;">图1 C23抗体蛋白质印迹分析结果图</span></p> <p><span style="color: #000000;">（货号：K106819P）</span></p> </section> <p>&nbsp;</p> <section style="color: #3e3e3e;"> <section></section> </section> <section style="color: #3e3e3e;"> <section> <p><span style="color: #000000;"><strong>NIFK</strong>（Nucleolar protein interacting with the FHA domain of pKI 67）是一种在核仁中发现的蛋白质，与MKI67的FHA结构域相互作用。NIFK与细胞周期进程和有丝分裂密切相关，其编码的蛋白质可以与Ki67抗原的FHA结构域相互作用，这种相互作用对于细胞周期的调控和细胞的增殖具有重要意义。</span></p> </section> </section> <section style="color: #3e3e3e;"> <section><span style="color: #000000;"><img class="rich_pages wxw-img" src="https://img45.chem17.com/9/20240628/638551680827195020635.png" alt="图片" crossorigin="anonymous" data-imgfileid="502583120" data-ratio="1.005639097744361" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/doiafjfLyzUISu4J0w7b2kwM886QRHvh6OyQkZaZEJkvJJmyhpq7om1vs6OCoTghdHLzf5QXcjBsmnWrbasSMsw/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="532" data-original-style="vertical-align: middle;width: 100%;" data-index="6" data-fail="0" /></span></section> </section> <section style="color: #a0a0a0;"> <p><span style="color: #000000;">图2 NIFK抗体蛋白质印迹分析结果图</span></p> <p><span style="color: #000000;">（货号：K107386P）</span></p> </section> <section style="color: #3e3e3e;"> <section></section> </section> <section style="color: #3e3e3e;"> <section> <p><span style="color: #000000;"><strong>核仁纤维蛋白</strong>（Fibrillarin，简称FBL）是一种34 kDa的核仁RNA 2'-O-甲基转移酶，是一种高度保守的蛋白质，位于核仁的致密原纤维成分中。FBL在细胞增殖、衰老、肿瘤的发生和发展过程中发挥重要作用。</span></p> </section> </section> <section style="color: #3e3e3e;"> <section><span style="color: #000000;"><img class="rich_pages wxw-img" src="https://img45.chem17.com/9/20240628/638551680830320057637.png" alt="图片" crossorigin="anonymous" data-imgfileid="502583122" data-ratio="1.4146825396825398" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/doiafjfLyzUISu4J0w7b2kwM886QRHvh6OdedZ5GGOkCKsAm4QicwoPhxT9BoOErW3zcj8bwIFRXUxTzUohluvmg/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="504" data-original-style="vertical-align: middle;width: 100%;" data-index="8" data-fail="0" /></span></section> </section> <section style="color: #a0a0a0;"> <p><span style="color: #000000;">图3 &nbsp;FBL抗体免疫组化结果图</span></p> <p><span style="color: #000000;">（货号：K113014P）</span></p> </section> <p>&nbsp;</p> <section> <p><span style="color: #000000;">已有一些蛋白被鉴定可用作核仁标志物（见表1）。</span></p> <p>&nbsp;</p> </section> <section style="color: #3e3e3e;"> <section> <section> <section style="color: #ffffff;"> <p><span style="color: #000000;"><strong>表 1细胞核标志物</strong></span></p> </section> </section> </section> </section> <p style="color: #3e3e3e;"><span style="color: #000000;"><img class="rich_pages wxw-img" src="https://img55.chem17.com/9/20240628/638551680832866810159.jpg" alt="图片" crossorigin="anonymous" data-cropselx1="0" data-cropselx2="578" data-cropsely1="0" data-cropsely2="1122" data-galleryid="" data-imgfileid="502583139" data-ratio="1.9425925925925926" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_jpg/doiafjfLyzUISu4J0w7b2kwM886QRHvh6WLbUHMu01Lr8zFSYUhebJru7sOEcYUUT25vhoq2WketlNXNa6ckQiaA/640?wx_fmt=jpeg&amp;from=appmsg" data-type="jpeg" data-w="1080" data-original-style="width: 578px;height: 1123px;" data-index="9" data-fail="0" /></span></p> <p>&nbsp;</p> <section style="color: #3e3e3e;"> <section></section> </section> <section style="color: #3e3e3e;"> <section> <section> <section> <section> <section> <p>&nbsp;</p> </section> </section> </section> </section> </section> <section> <section> <section style="color: #ffffff;"> <p><span style="color: #000000;"><strong>相关产品</strong></span></p> </section> </section> </section> <section> <section> <section> <section> <section> <section> <p>&nbsp;</p> </section> </section> </section> </section> </section> </section> </section> <section style="color: #3e3e3e;"> <section> <div class="tabledivclass"> <table width="677" align="left"> <tbody> <tr class="firstRow"> <td colspan="1" rowspan="1" width="35.0000%"> <section style="color: #ffffff;"> <p><span style="color: #000000;"><strong>产品货号</strong></span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section style="color: #ffffff;"> <p><span style="color: #000000;"><strong>产品名称</strong></span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K000339P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-FBL</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K113014P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-FBL</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K004294P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-NCL</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K106819P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-NCL</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K009398P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-NOP2</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K107386P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-NIFK</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K003007P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-EIF6</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> <tr> <td colspan="1" rowspan="1" width="35.0000%"> <section> <p><span style="color: #000000;">K108036P</span></p> </section> </td> <td colspan="1" rowspan="1" width="64.1600%"> <section> <p><span style="color: #000000;">Anti-EIF6</span></p> <p><span style="color: #000000;">Polyclonal Antibody</span></p> </section> </td> </tr> </tbody> </table> </div> </section> </section> <p>&nbsp;</p> <p>&nbsp;</p> <p>&nbsp;</p>