CAS Number: 64-86-8 
Empirical Formula (Hill Notation): C22H25NO6 
Molecular Weight: 399.44 
Beilstein Registry Number: 2228813 
EC Number: 200-598-5 
MDL number: MFCD00078484 
PubChem Substance ID: 24278348 
Description
Biochem/physiol Actions Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. 



性质
assay ≥95% (HPLC) 
form powder 
color white to yellow with a green cast 
mp 150-160 °C (dec.)(lit.) 
solubility H2O: soluble10 mg/mL 
Gene Information Research your gene in Your Favorite Gene powered by Ingenuity
human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669) 



安全性
Symbol GHS06, GHS08 
Signal word Danger 
Hazard statements H300-H340 
Precautionary statements P201-P264-P301 + P310-P308 + P313 
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
Hazard Codes T+ 
Risk Statements 26/28 
Safety Statements 13-45 
RIDADR UN 1544 6.1/PG 1 
WGK Germany 3 
RTECS GH0700000 
参考文献
reference Luduena, R.F., et al., Tubulin structure and biochemistry. Curr. Opin. Cell Biol. 4, 53-57, (1992) Abstract 
  Jordan, A., et al., Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev. 18, 259-296, (1998) Abstract 
  Andreu, J.M., et al., Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. Biochemistry 37, 8356-8368, (1998) Abstract 
  Banerjee, A., Differential effects of colchicine and its B-ring modified analog MTPT on the assembly-independent GTPase activity of purified β-tubulin isoforms from bovine brain. Biochem. Biophys. Res. Commun. 231, 698, (1997) Abstract 
  Suzuki, Y, Cell death, phagocytosis, and neurogenesis in mouse olfactory epithelium and vomeronasal organ after colchicine treatment. Ann. N.Y. Acad. Sci. 30, 252-254, (1998) 
  DeVincenzo, R., et al., Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anticancer Drug Des. 13, 19-33, (1998) Abstract 
  Ceccatelli, S., et al., Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. Neuroreport 8, 3779-3783, (1997) Abstract 
  Want, T.H., et al., Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273, 4928-4936, (1998) Abstract 
Merck Merck 14,2471 
Beilstein Beil. 14,IV,946 
  Aldrich MSDS 1, 482:D / Corp MSDS 1 (1), 903:B / FT-IR 1 (2), 361:C / FT-IR 2 (2), 2980:D / FT-NMR 1 (2), 1374:C / IR-Spectra (3), 1072:F / IR-Spectra (2), 938:B / NMR-Reference 2 (2), 340:A / RegBook 1 (2), 2007:C / Sigma FT-IR 1 (2), 403:C / Structure Index 1, 320:D:5