PTPRN monoclonal antibody, clone AFT38
产品名称： PTPRN monoclonal antibody, clone AFT38
英文名称： PTPRN monoclonal antibody, clone AFT38
产品编号： MAB2710
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152
- 传真 : +886-2-8751-1186
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant PTPRN.
- Immunogen:
- Recombinant protein corresponding to human PTPRN.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M.Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):674-9. Epub 2008 Jan 4.
- 2.
- Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.
Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR.J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29.
- 3.
- RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.
Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL.J Endocrinol. 2007 Nov;195(2):313-21.
- Applications
- Western Blot (Transfected lysate)
- Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPRN (709-979 a. a.).
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
- Entrez GeneID:
- 5798
- Gene Name:
- PTPRN
- Gene Alias:
- FLJ16131,IA-2,IA-2/PTP,IA2,ICA512,R-PTP-N
- Gene Description:
- protein tyrosine phosphatase, receptor type, N
- Omim ID:
- 601773
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. [provided by RefSeq
- Other Designations:
- islet cell antigen 2,islet cell antigen 512,islet cell autoantigen 3,protein tyrosine phosphatase-like N
- Gene Pathway
- Related Disease