SRD5A1 Pre-design Chimera RNAi
产品名称： SRD5A1 Pre-design Chimera RNAi
英文名称： SRD5A1 Pre-design Chimera RNAi
产品编号： H00006715-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
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- Specification
- Product Description:
- Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (SRD5A1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_001047
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 6715
- Gene Name:
- SRD5A1
- Gene Alias:
- -
- Gene Description:
- steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
- Omim ID:
- 184753
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM
- Other Designations:
- 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1,5-alpha reductase,OTTHUMP00000115519,steroid 5-alpha-reductase type I,steroid-5-alpha-reductase 1
- Gene Pathway
- Related Disease
- Alopecia
- Asperger Syndrome
- Atherosclerosis
- Autistic Disorder
- Breast Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hirsutism
- Hyperandrogenism
- Kidney Failure, Chronic
- Lymphoma, Non-Hodgkin
- Male pattern baldness
- Neoplasms, Glandular and Epithelial
- Obesity
- Ovarian cancer
- Ovarian Failure, Premature
- Ovarian Neoplasms