HTRA1 (N-term) Peptide
产品名称： HTRA1 (N-term) Peptide
英文名称： HTRA1 (N-term) Peptide
产品编号： P0340
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of HTRA1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 124-153 at N-terminus of human HTRA1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Clinical and genetic characteristics of hereditary pancreatitis in Europe.
Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP.Clin Gastroenterol Hepatol. 2004 Mar;2(3):252-61.
- 2.
- A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.
Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V.Oncogene. 2004 Feb 26;23(8):1636-44.
- 3.
- Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage.
Hu SI, Carozza M, Klein M, Nantermet P, Luk D, Crowl RM.J Biol Chem. 1998 Dec 18;273(51):34406-12.
- Applications
- Western Blot (Tissue lysate)
- The HTRA1 polyclonal antibody (Cat # PAB2455) is used in Western blot to detect HTRA1 mouse brain tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinomareacted with HTRA1 polyclonal antibody (Cat # PAB2455), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5654
- Protein Accession#:
- NP_002766;Q92743
- Gene Name:
- HTRA1
- Gene Alias:
- ARMD7,HtrA,L56,ORF480,PRSS11
- Gene Description:
- HtrA serine peptidase 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq
- Other Designations:
- IGFBP5-protease,OTTHUMP00000063514,protease, serine, 11 (IGF binding),serine protease 11
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Arthritis, Rheumatoid
- Atherosclerosis
- Blindness
- Calcinosis
- Cardiovascular Diseases
- Choroid Diseases
- Choroidal Neovascularization
- Choroiditis
- Coronary Artery Disease
- Depressive Disorder
- Diabetes Mellitus, Type 2
- Diabetic Retinopathy
- Disease Progression
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Geographic Atrophy