CA9 polyclonal antibody
产品名称： CA9 polyclonal antibody
英文名称： CA9 polyclonal antibody
产品编号： PAB4680
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CA9.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human CA9.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E.Oncogene. 2004 Jul 22;23(33):5624-31.
- 2.
- DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.
Kaluzova M, Kaluz S, Lerman MI, Stanbridge EJ.Mol Cell Biol. 2004 Jul;24(13):5757-66.
- 3.
- Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome.
Span PN, Bussink J, Manders P, Beex LV, Sweep CG.Br J Cancer. 2003 Jul 21;89(2):271-6.
- Entrez GeneID:
- 768
- Protein Accession#:
- NP_001207;Q16790
- Gene Name:
- CA9
- Gene Alias:
- CAIX,MN
- Gene Description:
- carbonic anhydrase IX
- Omim ID:
- 603179
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022773,RCC-associated protein G250,carbonic dehydratase
- Gene Pathway