CYP3A4 polyclonal antibody
产品名称: CYP3A4 polyclonal antibody
英文名称: CYP3A4 polyclonal antibody
产品编号: PAB7000
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of CYP3A4.
- Immunogen:
- A synthetic peptide corresponding to human CYP3A4.
- Sequence:
- C-KESRLEDTQKHR
- Host:
- Goat
- Theoretical MW (kDa):
- 57.3
- Specificity:
- This antibody is not expected to cross-react with 3A5, 3A7 ot 3A43.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:8000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.
Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR.Drug Metab Dispos. 2005 Jun;33(6):714-8. Epub 2005 Mar 11.
- Application Image
- ELISA
- Entrez GeneID:
- 1576
- Protein Accession#:
- NP_059488.2
- Gene Name:
- CYP3A4
- Gene Alias:
- CP33,CP34,CYP3A,CYP3A3,HLP,MGC126680,NF-25,P450C3,P450PCN1
- Gene Description:
- cytochrome P450, family 3, subfamily A, polypeptide 4
- Omim ID:
- 124010
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq
- Other Designations:
- P450-III, steroid inducible,cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3,cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4,cytochrome P450, subfamily IIIA, polypeptide 4,glucocorticoid-inducible P450,nifedipine o
- Related Disease
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Adenocarcinoma
- Adenoma, Liver Cell
- Akathisia, Drug-Induced
- Anemia
- Anemia, Aplastic
- Asthma
- Asthma
- Balkan Nephropathy
- Body Weight
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell
- Carcinoma, Small Cell