1) Cat. No.: TRC-I882200; 2) Chemical Name: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride ; 3) CAS No.: 103745-39-7; 4) Mol. Formula: C14H19Cl2N3O2S; 5) Mol. Weight: 364.28; 6) Packing Size: 25mg / 250mg; 7) Appearence: White to Off-White Solid; 8) Application Notes: A potent calcium antagonist vasodilator which is considered to act by employing different  mechanisms from the usual calcium channel blockers since it inhibits (1) calcium  ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular  space.   Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
; 9) Synonym: HA1077, Fasudil; 10) Solubility: Methanol, Water; 11) Storage condition: -20°C Freezer; 12) References: Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),