上皮细胞-间质转化基因表达PCR芯片
产品名称： 上皮细胞-间质转化基因表达PCR芯片
英文名称： Epithelial to Mesenchymal Transition (EMT) PCR Array
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产品价格： 4000
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上海杏园生物科技有限公司
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- 所在区域 : 上海
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- 邮箱 : info@xybiotech.com
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上皮细胞-间质转化基因表达PCR芯片可用于研究在这个过程中表达变化或者调控基因表达变化的84个关键基因的表达。该芯片包括细胞表面受体，细胞外基质，细胞骨架基因介导的细胞黏附、迁移、运动和形态，控制细胞分化、发育、生长和增殖的基因，以及导致EMT和所有相关的进程的信号转导和转录因子基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测参与肿瘤代谢或干细胞分化和发育有关的基因表达。Genes Up-Regulated During EMT: AHNAK, BMP1, CALD1, CAMK2N1, CDH2,COL1A2, COL3A1, COL5A2, FN1, FOXC2, GNG11, GSC, IGFBP4, ITGA5, ITGAV,MMP2, MMP3, MMP9, MSN, SERPINE1, SNAI1, SNAI2, SNAI3, SOX10, SPARC,STEAP1, TCF4, TIMP1, TMEFF1, TMEM132A, TWIST1, VCAN, VIM, VPS13A, WNT5A,WNT5B. Genes Down-Regulated During EMT: CAV2, CDH1 (E-cadherin), DSP,FGFBP1, IL1RN, KRT19, MST1R, NUDT13, OCLN, PPPDE2, RGS2, SPP1(Osteopontin), TFPI2, TSPAN13. Differentiation & Development: AKT1,BMP1, BMP2, BMP7, COL3A1, COL5A2, CTNNB1, DSP, ERBB3, F11R, FOXC2, FZD7,GSC, JAG1, KRT14, MST1R, NODAL, NOTCH1, PTP4A1, SMAD2, SNAI1, SNAI2,SOX10, TGFB2, TGFB3, TMEFF1, TWIST1, VCAN, WNT11, WNT5A, WNT5B.Morphogenesis: CTNNB1, FOXC2, JAG1, RAC1, SMAD2, SNAI1, SOX10, TGFB1,TGFB2, TGFB3, TWIST1, WNT11, WNT5A. Cell Growth & Prolifeion: AKT1,BMP1, BMP7, CAV2, CTNNB1, EGFR, ERBB3, FGFBP1, FOXC2, IGFBP4, ILK, JAG1,MST1R, NODAL, PDGFRB, TGFB1, TGFB2, TGFB3, TIMP1, VCAN, ZEB1. Migion& Motility: CALD1, CAV2, EGFR, FN1, ITGB1, JAG1, MSN, MST1R, NODAL,PDGFRB, RAC1, STAT3, TGFB1, VIM. Cytoskeleton: CAV2, KRT7, MAP1B,PLEK2, RAC1, VIM. Extracellular Matrix & Cell Adhesion: BMP1, BMP7,CDH1 (E-cadherin), CDH2 (N-cadherin), COL1A2, COL3A1, COL5A2, CTNNB1,DSC2, EGFR, ERBB3, F11R, FN1, FOXC2, ILK, ITGA5, ITGAV, ITGB1, MMP2,MMP3, MMP9, PTK2, RAC1, SERPINE1 (PAI-1), SPP1 (Osteopontin), TGFB1,TGFB2, TIMP1, VCAN. Signaling PAthways: Estrogen Receptor: CAV2, ESR1(ERa), KRT19, TGFB3. G-Protein Coupled Receptor: AKT1, FZD7, GNG11,RAC1, RGS2. Integrin-Mediated: COL3A1, ILK, ITGA5, ITGAV, ITGB1, PTK2.Notch: FOXC2, JAG1, NOTCH1. Receptor Tyrosine Kinase: EGFR, ERBB3,PDGFRB, RGS2, SPARC. TGFß / BMP: BMP1, BMP2, BMP7, COL3A1, SMAD2,TGFB1, TGFB2, TGFB3. WNT: CTNNB1, FZD7, GSK3B, WNT11, WNT5A, WNT5B.Transcription Factors: CTNNB1, ESR1 (ERa), FOXC2, GSC, NOTCH1, SIP1,SMAD2, SNAI2, SNAI3, SOX10, STAT3, TCF3, TCF4, TWIST1, ZEB1, ZEB2.
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