Polyclonal Rabbit Anti-Human Heparanase 1(HPA1) Antibody                                  Download as PDF

Introduction: 
Heparanase is an endo β-D-glucuronidase, which degrades heparin sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes (1,2,3). Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis (4,5). Heparanase is a heterodimer comprised of a 50 kDa subunit harbo