MMP15 polyclonal antibody
产品名称： MMP15 polyclonal antibody
英文名称： MMP15 polyclonal antibody
产品编号： PAB4783
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MMP15.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MMP15.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.
Jung M, Romer A, Keyszer G, Lein M, Kristiansen G, Schnorr D, Loening SA, Jung K.Prostate. 2003 May 1;55(2):89-98.
- 2.
- Matrix metalloproteinases.
Nagase H, Woessner JF Jr.J Biol Chem. 1999 Jul 30;274(31):21491-4.
- 3.
- Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA.
Matsumoto S, Katoh M, Saito S, Watanabe T, Masuho Y.Biochim Biophys Acta. 1997 Nov 1;1354(2):159-70.
- Applications
- Western Blot
- The MMP15 polyclonal antibody (Cat # PAB4783) is used in Western blot to detect MMP15 in mouse brain tissue lysate (lane 1) and HL-60 cell lysate (lane 2) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human colon carcinomareacted with MMP15 polyclonal antibody (Cat # PAB4783), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4324
- Protein Accession#:
- MM15_HUMAN
- Gene Name:
- MMP15
- Gene Alias:
- MT2-MMP,MTMMP2,SMCP-2
- Gene Description:
- matrix metallopeptidase 15 (membrane-inserted)
- Omim ID:
- 602261
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq
- Other Designations:
- matrix metalloproteinase 15,matrix metalloproteinase 15 (membrane-inserted),membrane-type matrix metalloproteinase 2,membrane-type-2 matrix metalloproteinase