SELL monoclonal antibody, clone DREG56
产品名称： SELL monoclonal antibody, clone DREG56
英文名称： SELL monoclonal antibody, clone DREG56
产品编号： MAB8213
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native SELL.
- Immunogen:
- Native purified SELL from PMA-activated human peripheral blood leukocytes.
- Host:
- Mouse
- Theoretical MW (kDa):
- 65-76
- Reactivity:
- Human
- Specificity:
- This antibody recognizes SELL, a 65-76 KDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (2 mg/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.
Killock DJ, Parsons M, Zarrouk M, Ameer-Beg SM, Ridley AJ, Haskard DO, Zvelebil M, Ivetic A.J Biol Chem. 2009 Mar 27;284(13):8833-45. Epub 2009 Jan 7.
- 2.
- Critical role of Lck in L-selectin signaling induced by sulfatides engagement.
Xu T, Chen L, Shang X, Cui L, Luo J, Chen C, Ba X, Zeng X.J Leukoc Biol. 2008 Oct;84(4):1192-201. Epub 2008 Jul 23.
- 3.
- L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts.
Jutila MA, Kurk S, Jackiw L, Knibbs RN, Stoolman LM.J Immunol. 2002 Aug 15;169(4):1768-73.
- 4.
- Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep.
Abraham WM, Ahmed A, Sabater JR, Lauredo IT, Botvinnikova Y, Bjercke RJ, Hu X, Revelle BM, Kogan TP, Scott IL, Dixon RA, Yeh ET, Beck PJ.Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1205-14.
- 5.
- Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro.
Kishimoto TK, Warnock RA, Jutila MA, Butcher EC, Lane C, Anderson DC, Smith CW.Blood. 1991 Aug 1;78(3):805-11.
- Application Image
- Western Blot
- Immunohistochemistry (Frozen sections)
- Immunoprecipitation
- ELISA
- Functional Study
- Flow Cytometry
- Entrez GeneID:
- 6402
- Gene Name:
- SELL
- Gene Alias:
- CD62L,LAM-1,LAM1,LECAM1,LNHR,LSEL,LYAM1,Leu-8,Lyam-1,PLNHR,TQ1,hLHRc
- Gene Description:
- selectin L
- Gene Ontology:
- Hyperlink
- Gene Summary:
- SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. [provided by RefSeq
- Other Designations:
- Leu-8 antigen,leukocyte adhesion molecule-1,lymph node homing receptor,lymphocyte adhesion molecule 1
- Gene Pathway
- Related Disease
- Acute Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Asthma
- Asthma
- Atherosclerosis
- Bronchiolitis, Viral
- Bronchopulmonary Dysplasia
- Brucellosis
- Cadaver
- Cardiovascular Diseases
- Celiac Disease
- Cerebrovascular Disorders
- Coronary Artery Disease
- Coronary Disease
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetes, type 1