FITC标记的脑低密度脂蛋白受体蛋白1抗体
产品名称： FITC标记的脑低密度脂蛋白受体蛋白1抗体
英文名称： Anti-NETO1/FITC
产品编号： HZ-8588R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
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Rabbit Anti-NETO1/FITC Conjugated antibody
FITC标记的脑低密度脂蛋白受体蛋白1抗体
| 产品编号 | bs-8588R-FITC |
| 英文名称 | Anti-NETO1/FITC |
| 中文名称 | FITC标记的脑低密度脂蛋白受体蛋白1抗体 |
| 别 名 | BCTL1; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; BTCL1; Neto1; NETO1_HUMAN; Neuropilin and tolloid like 1; Neuropilin and tolloid-like protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NETO1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NETO1 is a 533 amino acid protein that contains one LDL-receptor class A domain and two CUB domains and is either membrane-bound or secreted. Expressed as three alternatively spliced isoforms, the first two of which are retina-specific and the third of which is found in both retina and brain tissue, NETO1 is thought to be involved in the development and maintenance of neuronal circuitry, possibly playing a role in proper brain function. Human NETO1 shares 95% amino acid identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding NETO1 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory. Subunit: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains. Subcellular Location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Component of the postsynaptic density (PSD) of excitatory synapses. Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 1: Secreted (Potential). Tissue Specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. Similarity: Contains 2 CUB domains. Contains 1 LDL-receptor class A domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NETO1是包含一个LDL受体A类结构域和两个CuB结构域的533个氨基酸的蛋白质，并被膜结合或分泌。表现为三个交替剪接的亚型，前两个是视网膜特异性的，其中第三个在视网膜和脑组织中发现，NETO1被认为参与了神经元电路的发育和维持，可能在适当的脑功能中发挥作用。人NETO1与它的小鼠对应共有95%个氨基酸的同源性，表明物种之间具有保守的作用。编码NETO1的基因映射到人类18号染色体，它含有超过300个蛋白质编码基因，并含有近7600万个碱基。在染色体18定位基因中存在多种疾病，其中一些包括三体性18（也称为爱德华兹综合征）、尼曼-匹克病、遗传性出血性毛细血管扩张症、红细胞生成性原卟啉症和滤泡性淋巴瘤。