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Insulin-like Growth Factor I ( IGF-I / IGF1 ) Protein
 
 
 
 
 
 
 
IGF-I / IGF1 Protein Price Inquiry ( Available Sizes )
 
 
 
500μg:  询价;
 
≥1mg 大包装:  询价
 
 
 
IGF-I / IGF1蛋白产品信息
 
 
 
 
别名:
 
 
IGF-I, IGF1A,  IGFI
 
 
 
 
表达方式:
 
 
A DNA sequence encoding the mature form of human IGF1 isoform 1 ( P05019-1 ) ( Gly 49 - Ala 118 ) was fused with the polyhistidine-tagged NusA tag at the N-terminus
 
 
 
 
种属:
 
Human
 
 
 
表达宿主: 
 
E.coli
 
 
 
 
IGF-I / IGF1蛋白质控指标
 
 
 
 
纯度:
 
>  94 % as determined by SDS-PAGE
 
SDS-PAGE:
 
 
IGF1 protein
 
 
 
 
内毒素:
 
< 1.0 EU per μg of the protein as determined by the LAL method
 
 
 
稳定性:
 
Samples are stable for up to twelve months from date of receipt at -70℃
 
 
 
预测N端:
 
Met
 
 
 
分子量:
 
 
The recombinant human IGF1/NusA chimera consisting of 583 amino acids and has a calculated molecular mass of 64.8 kDa. It migrates as a 63 kDa band in SDS-PAGE under reducing conditions
 
 
 
 
缓冲液:
 
Lyophilized from sterile PBS , pH 7.4 
 
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
 
Please contact us for any concerns or special requirements.
 
 
 
 
 
 
IGF-I / IGF1蛋白使用指南
 
 
 
 
储存方法:
 
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
 
 
 
 
 
Reconstitution:
 
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 
 
 
 
IGF-I / IGF1蛋白相关产品和研究主题
 
 
相关领域:
 
Cancer>>Growth Factor & Receptor>>IGF System>>IGF-1/IGF-I
 
Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>IGF-1/IGF-I
 
Proteins:
 
Antibodies:
 
 
IGF-I / IGF1蛋白背景综述
 
 
Insulin-like growth factor I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development.
 IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
 
参考文献
 
 
 
Dull T.J. et al., 1984, Nature. 310:777-81.
 
Bell G.I. et al., 1984, Nature. 310:775-7.
 
Cooke R.M. et al., 1991, Biochemistry 30:5484-91.
 
Sandberg-Nordqvist A.-C . et al., 1992, Brain Res. Mol. Brain Res. 12: 275 - 7.