DUSP4 monoclonal antibody, clone AFPK7
产品名称： DUSP4 monoclonal antibody, clone AFPK7
英文名称： DUSP4 monoclonal antibody, clone AFPK7
产品编号： MAB2704
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant DUSP4.
- Immunogen:
- Recombinant protein corresponding to human DUSP4.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Keyse SM.Cancer Metastasis Rev. 2008 Jun;27(2):253-61.
- 2.
- Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.
Teng CH, Huang WN, Meng TC.J Biol Chem. 2007 Sep 28;282(39):28395-407. Epub 2007 Aug 6.
- 3.
- Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis.
Shen WH, Wang J, Wu J, Zhurkin VB, Yin Y.Cancer Res. 2006 Jun 15;66(12):6033-9.
- Entrez GeneID:
- 1846
- Gene Name:
- DUSP4
- Gene Alias:
- HVH2,MKP-2,MKP2,TYP
- Gene Description:
- dual specificity phosphatase 4
- Omim ID:
- 602747
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq
- Other Designations:
- MAP kinase phosphatase 2,VH1 homologous phosphatase 2,serine/threonine specific protein phosphatase
- Gene Pathway